Research workbench
Crystal structure of the protein O27018 from methanobacterium thermoautotrophicum. northeast structural genomics consortium target TT217
Analyse Crystal structure of the protein O27018 from methanobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BEY
- Type
- protein
- Length
- 543 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved protein O27018
- UniProt
- O27018
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 5 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Conserved protein O27018 | protein | 89 | 79% helix, 0% strand | O27018 |
| B | Conserved protein O27018 | protein | 89 | 74% helix, 0% strand | O27018 |
| C, F | Conserved protein O27018 | protein | 92 | 80% helix, 0% strand | O27018 |
| D | Conserved protein O27018 | protein | 94 | 74% helix, 0% strand | O27018 |
| E | Conserved protein O27018 | protein | 87 | 80% helix, 0% strand | O27018 |
Pockets
7 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 510 | 0.78 | 0.86 | 42 | empty |
| 2 | 142 | 0.67 | 0.88 | 25 | empty |
| 3 | 196 | 0.65 | 0.84 | 26 | empty |
| 4 | 185 | 0.61 | 0.82 | 25 | empty |
| 5 | 189 | 0.59 | 0.81 | 34 | empty |
Interfaces
15 interfaces between chains.
- D–F · 2106 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 2080 Ų buried · 8 hydrogen bonds · protein-protein
- B–E · 1864 Ų buried · 8 hydrogen bonds · protein-protein
- C–F · 1263 Ų buried · 18 hydrogen bonds · protein-protein
- D–E · 1254 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 6 modified (disulfide, engineered).
Compared structures
- 3BEY · Crystal structure of the protein O27018 from Methanobacterium thermoautotrophicum.… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O27018
- Elsewhere: RCSB PDB 3BEY · PDBe 3BEY · UniProt O27018
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