Research workbench
11MER structure of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding
Analyse 11MER structure of an MHC class I molecule from B21 chickens illustrate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BEV
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major histocompatibility complex class I glycoprotein haplotype B21…
- UniProt
- Q95601, P21611, P01994
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major histocompatibility complex class I glycoprotein haplotype B21 | protein | 274 | 26% helix, 39% strand | Q95601 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P21611 |
| C | Hemoglobin subunit alpha-a | protein | 11 | 36% helix, 0% strand | P01994 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 607 | 0.68 | 0.77 | 54 | empty |
| 2 | 53 | 0.50 | 0.87 | 22 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1614 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 913 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3BEV · 11mer Structure of an MHC class I molecule from B21 chickens illustrate promiscuous… · the same entry in another collection · chain A against A, TM-score 1.00
- P21611 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P21611) · a predicted model of the same protein · chain B against A, TM-score 0.97
- P01994 · AlphaFold monomer V2.0 prediction for hemoglobin subunit alpha-a (P01994) · a predicted model of the same protein · chain C against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q95601
- Every structure of UniProt P21611
- Every structure of UniProt P01994
- Elsewhere: RCSB PDB 3BEV · PDBe 3BEV · UniProt Q95601 · UniProt P21611 · UniProt P01994
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