Research workbench
Crystal structure of memo
Analyse Crystal structure of memo in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BCZ
- Type
- protein
- Length
- 1,171 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein MEMO1
- UniProt
- Q9Y316
- Pockets
- 13 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Protein MEMO1 | protein | 293 | 40% helix, 22% strand | Q9Y316 |
| C | Protein MEMO1 | protein | 292 | 40% helix, 23% strand | Q9Y316 |
Ligands and binding sites
- GOL · Glycerol · additive · 5 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.81 | 0.82 | 90 | empty |
| 2 | 406 | 0.57 | 0.75 | 34 | empty |
| 3 | 147 | 0.50 | 0.79 | 26 | empty |
| 4 | 223 | 0.49 | 0.74 | 20 | empty |
| 5 | 124 | 0.44 | 0.77 | 28 | empty |
Interfaces
5 interfaces between chains.
- A–B · 565 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 459 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 345 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 300 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y316
- Elsewhere: RCSB PDB 3BCZ · PDBe 3BCZ · UniProt Q9Y316
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