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Conformational changes of the acrr regulator reveal a mechanism of induction

Analyse Conformational changes of the acrr regulator reveal a mechanism of induction in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3BCG
Type: protein
Length: 414 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hth-type transcriptional regulator acrr
UniProt: P0ACS9
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hth-type transcriptional regulator acrr	protein	207	67% helix, 0% strand	P0ACS9

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	563	0.81	0.86	55	empty
2	571	0.78	0.84	57	empty

Interfaces

1 interface between chains.

A–B · 2128 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

3BCG · Conformational changes of the AcrR regulator reveal a mechanism of induction · the same entry in another collection · chain A against A, TM-score 1.00
P0ACS9 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator acrr (P0ACS9) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0ACS9
Elsewhere: RCSB PDB 3BCG · PDBe 3BCG · UniProt P0ACS9

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