Research workbench

Crystal structure of murine interleukin-5

Analyse Crystal structure of murine interleukin-5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3B5K
Type: protein
Length: 211 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-5
UniProt: P04401
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 2 distinct chains · 61% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-5	protein	105	63% helix, 6% strand	P04401
B	Interleukin-5	protein	106	59% helix, 6% strand	P04401

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	104	0.40	0.76	18	empty
2	64	0.29	0.73	19	empty

Interfaces

1 interface between chains.

A–B · 3339 Å² buried · 31 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3B5K · Crystal structure of murine interleukin-5 · the same entry in another collection · chain A against A, TM-score 1.00
P04401 · AlphaFold monomer V2.0 prediction for interleukin-5 (P04401) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04401
Elsewhere: RCSB PDB 3B5K · PDBe 3B5K · UniProt P04401

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.