Research workbench
The 2.4 a crystal structure of the apo catalytic domain of coactivator-associated arginine methyl transferase I(CARM1,140-480).
Analyse The 2.4 a crystal structure of the apo catalytic domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3B3G
- Type
- protein
- Length
- 648 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-arginine methyltransferase CARM1
- EC
- 2.1.1.125, 2.1.1.-
- UniProt
- Q4AE70
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Histone-arginine methyltransferase CARM1 (EC 2.1.1.125, 2.1.1.-) | protein | 324 | 27% helix, 38% strand | Q4AE70 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 295 | 0.55 | 0.76 | 35 | empty |
| 2 | 291 | 0.55 | 0.76 | 33 | empty |
| 3 | 60 | 0.34 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1758 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 3B3G · The 2.4 A crystal structure of the apo catalytic domain of coactivator-associated… · the same entry in another collection · chain A against A, TM-score 1.00
- Q4AE70 · AlphaFold monomer V2.0 prediction for histone-arginine methyltransferase CARM1 (Q4AE70) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4AE70
- Elsewhere: RCSB PDB 3B3G · PDBe 3B3G · UniProt Q4AE70
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