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Crystal structure of human crhsp-24

Analyse Crystal structure of human crhsp-24 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3AQQ
Type
protein
Length
393 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Calcium-regulated heat stable protein 1
UniProt
Q9Y2V2
Pockets
2 · best druggability 0.60

Structure

x-ray diffraction · 4 distinct chains · 12% helix, 41% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ACalcium-regulated heat stable protein 1protein9912% helix, 41% strandQ9Y2V2
CCalcium-regulated heat stable protein 1protein9711% helix, 42% strandQ9Y2V2
BCalcium-regulated heat stable protein 1protein9911% helix, 37% strandQ9Y2V2
DCalcium-regulated heat stable protein 1protein9812% helix, 43% strandQ9Y2V2

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
13640.600.7644empty
2930.420.7820empty

Interfaces

4 interfaces between chains.

  • A–B · 1096 Ų buried · 23 hydrogen bonds · protein-protein
  • C–D · 1081 Ų buried · 22 hydrogen bonds · protein-protein
  • C–B · 605 Ų buried · 9 hydrogen bonds · protein-protein
  • B–D · 368 Ų buried · 2 hydrogen bonds · protein-protein

Compared structures

  • 3AQQ · Crystal structure of human CRHSP-24 · the same entry in another collection · chain D against D, TM-score 1.00
  • Q9Y2V2 · AlphaFold monomer V2.0 prediction for calcium-regulated heat-stable protein 1 (Q9Y2V2) · a predicted model of the same protein · chain D against A, TM-score 0.98

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