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Crystal structure of the measles virus hemagglutinin bound to its cellular receptor slam (form I, mv-H-SLAM(N102H/R108Y) fusion)
Analyse Crystal structure of the measles virus hemagglutinin bound to its cellular… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ALW
- Type
- protein
- Length
- 510 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin, CDW150
- UniProt
- E2RZS2, Q9GJT3
- Ligands
- NAG
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemagglutinin, CDW150 | protein | 510 | 5% helix, 45% strand | E2RZS2, Q9GJT3 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 271 | 0.80 | 0.91 | 40 | empty |
| 2 | 185 | 0.57 | 0.81 | 35 | empty |
| 3 | 172 | 0.53 | 0.79 | 28 | empty |
| 4 | 219 | 0.51 | 0.76 | 32 | empty |
| 5 | 56 | 0.47 | 0.84 | 15 | empty |
Modifications
Observed in the structure: 6 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 3ALW · Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2RZS2
- Every structure of UniProt Q9GJT3
- Elsewhere: RCSB PDB 3ALW · PDBe 3ALW · UniProt E2RZS2 · UniProt Q9GJT3
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