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Crystal structure of the hsaa monooxygenase from M. tuberculosis
Analyse Crystal structure of the hsaa monooxygenase from M. tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3AFF
- Type
- protein
- Length
- 730 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hydroxylase, putative
- UniProt
- P96852
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hydroxylase, putative | protein | 366 | 57% helix, 16% strand | P96852 |
| B | Hydroxylase, putative | protein | 364 | 57% helix, 16% strand | P96852 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 309 | 0.76 | 0.88 | 51 | empty |
| 2 | 323 | 0.75 | 0.86 | 49 | empty |
| 3 | 84 | 0.48 | 0.82 | 21 | empty |
| 4 | 83 | 0.47 | 0.81 | 20 | empty |
| 5 | 95 | 0.38 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 1042 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3AFF · Crystal structure of the HsaA monooxygenase from M. tuberculosis · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P96852
- Elsewhere: RCSB PDB 3AFF · PDBe 3AFF · UniProt P96852
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