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Crystal structure of ZN2+-bound form of DES3-20ALG-2F122A

Analyse Crystal structure of ZN2+-bound form of DES3-20ALG-2F122A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3AAK
Type: protein
Length: 167 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Programmed cell death protein 6
UniProt: O75340
Ligands: ZN
Pockets: 3 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 57% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Programmed cell death protein 6	protein	167	57% helix, 5% strand	O75340

Ligands and binding sites

ZN · Zinc ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.39	0.76	21	empty
2	83	0.38	0.76	13	empty
3	84	0.33	0.73	15	empty

Compared structures

3AAK · Crystal structure of Zn2+-bound form of des3-20ALG-2F122A · the same entry in another collection · chain A against A, TM-score 1.00
O75340 · AlphaFold monomer V2.0 prediction for programmed cell death protein 6 (O75340) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75340
Elsewhere: RCSB PDB 3AAK · PDBe 3AAK · UniProt O75340

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