Research workbench
Crystal structure of the mouse TAB3-nzf in complex with LYS63-linked di-ubiquitin
Analyse Crystal structure of the mouse TAB3-nzf in complex with LYS63-linked… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3A9K
- Type
- protein
- Length
- 182 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin; Mitogen-activated protein kinase kinase kinase 7- interacting protein 3
- UniProt
- P62991, Q571K4
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin | protein | 76 | 24% helix, 34% strand | P62991 |
| B | Ubiquitin | protein | 77 | 25% helix, 32% strand | P62991 |
| C | Mitogen-activated protein kinase kinase kinase 7- interacting protein 3 | protein | 29 | 0% helix, 21% strand | Q571K4 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 453 | 0.61 | 0.76 | 56 | empty |
Interfaces
3 interfaces between chains.
- A–C · 345 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 318 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 147 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
- 3A9K · Crystal structure of the mouse TAB3-NZF in complex with Lys63-linked di-ubiquitin · the same entry in another collection · chain A against A, TM-score 1.00
- Q571K4 · AlphaFold monomer V2.0 prediction for TGF-beta-activated kinase 1 and MAP3K7-binding… · a predicted model of the same protein · chain C against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62991
- Every structure of UniProt Q571K4
- Elsewhere: RCSB PDB 3A9K · PDBe 3A9K · UniProt P62991 · UniProt Q571K4
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