Research workbench
Crystal structure of TIM40/MIA40, a disulfide relay system in mitochondria, solved as mbp fusion protein
Analyse Crystal structure of TIM40/MIA40, a disulfide relay system in mitochondria… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZXT
- Type
- protein
- Length
- 451 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, linker, mitochondrial intermembrane space import and…
- UniProt
- P0AEX9, P36046
- Ligands
- GLC
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, linker, mitochondrial intermembrane space import and assembly protein 40 | protein | 451 | 43% helix, 15% strand | P0AEX9, P36046 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 285 | 0.73 | 0.86 | 28 | GLC |
| 2 | 292 | 0.64 | 0.81 | 38 | empty |
| 3 | 119 | 0.39 | 0.75 | 25 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2ZXT · Crystal structure of Tim40/MIA40, a disulfide relay system in mitochondria, solved as MBP… · the same entry in another collection · chain A against A, TM-score 1.00
- P36046 · AlphaFold monomer V2.0 prediction for mitochondrial intermembrane space import and… · a predicted model of the same protein · chain A against A, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P36046
- Elsewhere: RCSB PDB 2ZXT · PDBe 2ZXT · UniProt P0AEX9 · UniProt P36046
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