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Crystal structure of intimin-TIR90 complex

Analyse Crystal structure of intimin-TIR90 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2ZWK
Type
protein
Length
738 residues
Chains
6
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Intimin; Putative translocated intimin receptor protein (translocated intimin receptor…
UniProt
P43261, Q7DB77

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 31% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, C, EIntiminprotein18316% helix, 36% strandP43261
B, D, FPutative translocated intimin receptor protein (translocated intimin receptor tir)protein6348% helix, 19% strandQ7DB77

Interfaces

5 interfaces between chains.

  • A–B · 618 Ų buried · 14 hydrogen bonds · protein-protein
  • C–D · 604 Ų buried · 12 hydrogen bonds · protein-protein
  • E–F · 587 Ų buried · 9 hydrogen bonds · protein-protein
  • A–E · 187 Ų buried · 1 hydrogen bond · protein-protein
  • D–F · 113 Ų buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

  • 2ZWK · Crystal structure of intimin-Tir90 complex · the same entry in another collection · chain F against F, TM-score 1.00
  • P43261 · AlphaFold monomer V2.0 prediction for intimin (P43261) · a predicted model of the same protein · chain A against A, TM-score 0.99
  • Q7DB77 · AlphaFold monomer V2.0 prediction for translocated intimin receptor tir (Q7DB77) · a predicted model of the same protein · chain B against A, TM-score 0.93

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