Research workbench
Crystal structure of bleomycin N-acetyltransferase from bleomycin-producing streptomyces verticillus ATCC15003
Analyse Crystal structure of bleomycin N-acetyltransferase from bleomycin-producing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZW6
- Type
- protein
- Length
- 591 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bleomycin acetyltransferase
- UniProt
- Q53796
- Ligands
- SO4
- Pockets
- 7 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bleomycin acetyltransferase | protein | 297 | 25% helix, 32% strand | Q53796 |
| B | Bleomycin acetyltransferase | protein | 294 | 24% helix, 33% strand | Q53796 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 699 | 0.80 | 0.84 | 87 | empty |
| 2 | 295 | 0.72 | 0.85 | 40 | SO4 |
| 3 | 340 | 0.71 | 0.84 | 54 | SO4 |
| 4 | 291 | 0.65 | 0.82 | 30 | empty |
| 5 | 65 | 0.37 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2420 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 2ZW6 · Crystal structure of bleomycin N-acetyltransferase from bleomycin-producing Streptomyces… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q53796
- Elsewhere: RCSB PDB 2ZW6 · PDBe 2ZW6 · UniProt Q53796
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