Research workbench
Crystal structure of sufc-sufd complex involved in the iron- sulfur cluster biosynthesis
Analyse Crystal structure of sufc-sufd complex involved in the iron- sulfur cluster… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZU0
- Type
- protein
- Length
- 1,119 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein sufd; Probable ATP-dependent transporter sufc
- UniProt
- P77689, P77499
- Pockets
- 11 · best druggability 0.51
Structure
x-ray diffraction · 4 distinct chains · 26% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein sufd | protein | 416 | 21% helix, 40% strand | P77689 |
| B | Protein sufd | protein | 414 | 21% helix, 40% strand | P77689 |
| C | Probable ATP-dependent transporter sufc | protein | 247 | 36% helix, 26% strand | P77499 |
| D | Probable ATP-dependent transporter sufc | protein | 42 | 57% helix, 0% strand | P77499 |
Ligands and binding sites
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.51 | 0.79 | 32 | empty |
| 2 | 153 | 0.49 | 0.78 | 27 | empty |
| 3 | 108 | 0.47 | 0.80 | 19 | empty |
| 4 | 132 | 0.43 | 0.76 | 24 | empty |
| 5 | 150 | 0.42 | 0.75 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1544 Ų buried · 33 hydrogen bonds · protein-protein
- A–C · 922 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 588 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2ZU0 · Crystal structure of SufC-SufD complex involved in the iron-sulfur cluster biosynthesis · the same entry in another collection · chain D against D, TM-score 1.00
- P77689 · AlphaFold monomer V2.0 prediction for fes cluster assembly protein sufd (P77689) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P77499 · AlphaFold monomer V2.0 prediction for probable ATP-dependent transporter sufc (P77499) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P77689
- Every structure of UniProt P77499
- Elsewhere: RCSB PDB 2ZU0 · PDBe 2ZU0 · UniProt P77689 · UniProt P77499
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