Research workbench
Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase from aeropyrum pernix
Analyse Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase from aeropyrum… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZSL
- Type
- protein
- Length
- 420 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate-1-semialdehyde 2,1-aminomutase
- EC
- 5.4.3.8
- UniProt
- Q9Y9I9
- Ligands
- PMP
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate-1-semialdehyde 2,1-aminomutase (EC 5.4.3.8) | protein | 420 | 45% helix, 18% strand | Q9Y9I9 |
Ligands and binding sites
- PMP · 4'-deoxy-4'-aminopyridoxal-5'-phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.75 | 1.00 | 15 | empty |
| 2 | 340 | 0.58 | 0.76 | 46 | PMP |
| 3 | 193 | 0.49 | 0.75 | 23 | empty |
| 4 | 127 | 0.44 | 0.77 | 30 | empty |
| 5 | 91 | 0.39 | 0.77 | 18 | empty |
Compared structures
- 2ZSL · Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from Aeropyrum pernix · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y9I9 · AlphaFold monomer V2.0 prediction for glutamate-1-semialdehyde 2,1-aminomutase (Q9Y9I9) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y9I9
- Elsewhere: RCSB PDB 2ZSL · PDBe 2ZSL · UniProt Q9Y9I9
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