Research workbench
Crystal structure of intimin-TIR68 complex
Analyse Crystal structure of intimin-TIR68 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZQK
- Type
- protein
- Length
- 621 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intimin; Putative translocated intimin receptor protein (translocated intimin receptor…
- UniProt
- P43261, Q7DB77
- Pockets
- 3 · best druggability 0.32
Structure
x-ray diffraction · 4 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Intimin | protein | 183 | 15% helix, 38% strand | P43261 |
| M, C | Putative translocated intimin receptor protein (translocated intimin receptor tir) | protein | 64 | 64% helix, 19% strand | Q7DB77 |
| N, D | Putative translocated intimin receptor protein (translocated intimin receptor tir) | protein | 63 | 59% helix, 19% strand | Q7DB77 |
| B | Intimin | protein | 184 | 13% helix, 36% strand | P43261 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.32 | 0.76 | 12 | empty |
| 2 | 64 | 0.32 | 0.75 | 13 | empty |
| 3 | 52 | 0.32 | 0.77 | 13 | empty |
Interfaces
6 interfaces between chains.
- C–D · 772 Ų buried · 12 hydrogen bonds · protein-protein
- M–N · 739 Ų buried · 9 hydrogen bonds · protein-protein
- A–N · 620 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 614 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 106 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2ZQK · Crystal structure of intimin-Tir68 complex · the same entry in another collection · chain D against D, TM-score 1.00
- P43261 · AlphaFold monomer V2.0 prediction for intimin (P43261) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q7DB77 · AlphaFold monomer V2.0 prediction for translocated intimin receptor tir (Q7DB77) · a predicted model of the same protein · chain N against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43261
- Every structure of UniProt Q7DB77
- Elsewhere: RCSB PDB 2ZQK · PDBe 2ZQK · UniProt P43261 · UniProt Q7DB77
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