Research workbench
Crystal structure of the mouse radxin ferm domain complexed with the mouse CD44 cytoplasmic peptide
Analyse Crystal structure of the mouse radxin ferm domain complexed with the mouse CD44… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZPY
- Type
- protein
- Length
- 304 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Radixin; CD44 antigen
- UniProt
- P26043, P15379
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Radixin | protein | 295 | 36% helix, 25% strand | P26043 |
| B | CD44 antigen | protein | 9 | 0% helix, 56% strand | P15379 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 342 | 0.60 | 0.77 | 35 | empty |
| 2 | 338 | 0.59 | 0.77 | 28 | empty |
| 3 | 69 | 0.44 | 0.81 | 25 | empty |
| 4 | 92 | 0.41 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 525 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 2ZPY · Crystal structure of the mouse radxin FERM domain complexed with the mouse CD44… · the same entry in another collection · chain A against A, TM-score 1.00
- P26043 · AlphaFold monomer V2.0 prediction for radixin (P26043) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P15379 · AlphaFold monomer V2.0 prediction for CD44 antigen (P15379) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26043
- Every structure of UniProt P15379
- Elsewhere: RCSB PDB 2ZPY · PDBe 2ZPY · UniProt P26043 · UniProt P15379
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