Research workbench
The multi-drug binding transcriptional repressor cgmr (CGL2612 protein) from C.GLUTAMICUM
Analyse The multi-drug binding transcriptional repressor cgmr (CGL2612 protein) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZOY
- Type
- protein
- Length
- 347 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator
- UniProt
- Q8NMG3
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator | protein | 175 | 73% helix, 0% strand | Q8NMG3 |
| B | Transcriptional regulator | protein | 172 | 76% helix, 0% strand | Q8NMG3 |
Ligands and binding sites
- GOL · Glycerol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 177 | 0.63 | 0.84 | 33 | GOL |
| 2 | 119 | 0.57 | 0.84 | 16 | empty |
| 3 | 82 | 0.53 | 0.85 | 20 | GOL |
| 4 | 69 | 0.34 | 0.76 | 14 | empty |
| 5 | 55 | 0.33 | 0.78 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1947 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 2ZOY · The multi-drug binding transcriptional repressor CgmR (CGL2612 protein) from C.glutamicum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NMG3
- Elsewhere: RCSB PDB 2ZOY · PDBe 2ZOY · UniProt Q8NMG3
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