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The 1.37-a crystal structure of the hydroxylamine-induced deoxy-form of the copper-bound tyrosinase in complex with a caddie protein from streptomyces castaneoglobisporus
Analyse The 1.37-a crystal structure of the hydroxylamine-induced deoxy-form of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZMZ
- Type
- protein
- Length
- 352 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosinase; Caddie
- EC
- 1.14.18.1
- UniProt
- Q83WS2
- Ligands
- CU1, NO3
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosinase (EC 1.14.18.1) | protein | 273 | 42% helix, 5% strand | Q83WS2 |
| B | Caddie | protein | 79 | 15% helix, 42% strand | — |
Ligands and binding sites
- CU1 · Copper (I) ion · metal · 3 copies · chains A, B
- NO3 · Nitrate ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.44 | 0.79 | 23 | empty |
| 2 | 59 | 0.35 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1186 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 2ZMZ · The 1.37-A crystal structure of the hydroxylamine-induced deoxy-form of the copper-bound… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q83WS2
- Elsewhere: RCSB PDB 2ZMZ · PDBe 2ZMZ · UniProt Q83WS2
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