Research workbench
Crystal structural of mouse kynurenine aminotransferase III
Analyse Crystal structural of mouse kynurenine aminotransferase III in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZJG
- Type
- protein
- Length
- 820 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kynurenine-oxoglutarate transaminase 3
- EC
- 2.6.1.7, 2.6.1.63, 2.6.1.64
- UniProt
- Q71RI9
- Pockets
- 5 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Kynurenine-oxoglutarate transaminase 3 (EC 2.6.1.7, 2.6.1.63, 2.6.1.64) | protein | 410 | 41% helix, 16% strand | Q71RI9 |
Ligands and binding sites
- GOL · Glycerol · additive · 9 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 592 | 0.74 | 0.81 | 54 | GOL |
| 2 | 541 | 0.73 | 0.81 | 57 | GOL |
| 3 | 98 | 0.37 | 0.75 | 18 | empty |
| 4 | 85 | 0.33 | 0.74 | 18 | empty |
| 5 | 70 | 0.30 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2824 Ų buried · 50 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cofactor).
Compared structures
- 2ZJG · Crystal structural of mouse kynurenine aminotransferase III · the same entry in another collection · chain A against A, TM-score 1.00
- Q71RI9 · AlphaFold monomer V2.0 prediction for kynurenine--oxoglutarate transaminase 3 (Q71RI9) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71RI9
- Elsewhere: RCSB PDB 2ZJG · PDBe 2ZJG · UniProt Q71RI9
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