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Crystal structure of TTHA0409, putative DNA modification methylase from thermus thermophilus HB8

Analyse Crystal structure of TTHA0409, putative DNA modification methylase from thermus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ZIG
Type: protein
Length: 473 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative modification methylase
UniProt: Q5SL84
Pockets: 6 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative modification methylase	protein	236	36% helix, 27% strand	Q5SL84
B	Putative modification methylase	protein	237	36% helix, 24% strand	Q5SL84

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.59	0.78	42	empty
2	340	0.58	0.76	48	empty
3	168	0.56	0.81	25	empty
4	193	0.56	0.80	29	empty
5	67	0.47	0.83	20	empty

Interfaces

1 interface between chains.

A–B · 2519 Å² buried · 39 hydrogen bonds · protein-protein

Compared structures

2ZIG · Crystal Structure of TTHA0409, Putative DNA Modification Methylase from Thermus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SL84
Elsewhere: RCSB PDB 2ZIG · PDBe 2ZIG · UniProt Q5SL84

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