Research workbench
Structure of lactate oxidase at PH4.5 from aerococcus viridans
Analyse Structure of lactate oxidase at PH4.5 from aerococcus viridans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZFA
- Type
- protein
- Length
- 681 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lactate oxidase
- EC
- 1.13.12.4
- UniProt
- Q44467
- Ligands
- FMN
- Pockets
- 10 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lactate oxidase (EC 1.13.12.4) | protein | 352 | 41% helix, 15% strand | Q44467 |
| B | Lactate oxidase (EC 1.13.12.4) | protein | 329 | 43% helix, 15% strand | Q44467 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 194 | 0.80 | 0.94 | 34 | FMN, EDO |
| 2 | 198 | 0.79 | 0.94 | 35 | FMN, EDO |
| 3 | 96 | 0.67 | 0.91 | 21 | empty |
| 4 | 319 | 0.65 | 0.81 | 43 | empty |
| 5 | 94 | 0.47 | 0.81 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1079 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 2ZFA · Structure of Lactate Oxidase at pH4.5 from AEROCOCCUS VIRIDANS · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q44467
- Elsewhere: RCSB PDB 2ZFA · PDBe 2ZFA · UniProt Q44467
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.