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Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex with 1,25-dihydroxyvitamin D3
Analyse Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZBZ
- Type
- protein
- Length
- 404 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450-SU1
- EC
- 1.14.14.1
- UniProt
- P18326
- Ligands
- HEM, VDX
- Pockets
- 1 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450-SU1 (EC 1.14.14.1) | protein | 404 | 50% helix, 9% strand | P18326 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- VDX · 5-{2-[1-(5-hydroxy-1,5-dimethyl-hexyl)-7A-methyl-octahydro-inden-4-ylidene]-ethylidene}-4-methylene-cyclohexane-1,3-diol · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 799 | 0.88 | 0.91 | 73 | HEM, VDX |
Compared structures
- 2ZBZ · Crystal structure of vitamin D hydroxylase cytochrome P450 105A1 (R84A mutant) in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- P18326 · AlphaFold monomer V2.0 prediction for vitamin D3 dihydroxylase (P18326) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18326
- Elsewhere: RCSB PDB 2ZBZ · PDBe 2ZBZ · UniProt P18326
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