Research workbench
Crystal structure of uncharacterized conserved protein from thermotoga maritima
Analyse Crystal structure of uncharacterized conserved protein from thermotoga maritima in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ZBV
- Type
- protein
- Length
- 781 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized conserved protein
- UniProt
- Q9WZC8
- Ligands
- ADN
- Pockets
- 13 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 25% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized conserved protein | protein | 263 | 25% helix, 30% strand | Q9WZC8 |
| B | Uncharacterized conserved protein | protein | 258 | 24% helix, 30% strand | Q9WZC8 |
| C | Uncharacterized conserved protein | protein | 260 | 24% helix, 30% strand | Q9WZC8 |
Ligands and binding sites
- ADN · Adenosine · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.82 | 0.97 | 40 | ADN |
| 2 | 418 | 0.82 | 0.90 | 47 | empty |
| 3 | 151 | 0.81 | 0.97 | 30 | ADN |
| 4 | 131 | 0.80 | 0.97 | 26 | ADN |
| 5 | 139 | 0.52 | 0.80 | 23 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1329 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 1312 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 1300 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 2ZBV · Crystal structure of uncharacterized conserved protein from Thermotoga maritima · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WZC8
- Elsewhere: RCSB PDB 2ZBV · PDBe 2ZBV · UniProt Q9WZC8
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