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Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment of tnt

Analyse Crystal structure of the head-to-tail junction of tropomyosin complexed with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Z5H
Type: protein
Length: 475 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: General control protein GCN4 and tropomyosin alpha-1 chain; Tropomyosin alpha-1 chain and…
UniProt: P03069, P58772, P12620
Pockets: 2 · best druggability 0.71

Structure

x-ray diffraction · 5 distinct chains · 66% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D, E, H	General control protein GCN4 and tropomyosin alpha-1 chain	protein	49	90% helix, 0% strand	P03069, P58772
B, F	General control protein GCN4 and tropomyosin alpha-1 chain	protein	51	90% helix, 0% strand	P03069, P58772
C, G	General control protein GCN4 and tropomyosin alpha-1 chain	protein	52	88% helix, 0% strand	P03069, P58772
I	Tropomyosin alpha-1 chain and general control protein GCN4	protein	39	21% helix, 0% strand	P03069, P58772
T	Troponin T, fast skeletal muscle isoforms	protein	34	12% helix, 0% strand	P12620

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1097	0.71	0.75	92	empty
2	60	0.33	0.77	18	empty

Interfaces

16 interfaces between chains.

C–D · 1436 Å² buried · 2 hydrogen bonds · protein-protein
G–H · 1391 Å² buried · 2 hydrogen bonds · protein-protein
E–F · 1375 Å² buried · 3 hydrogen bonds · protein-protein
A–B · 1363 Å² buried · 2 hydrogen bonds · protein-protein
A–T · 520 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

2Z5H · Crystal structure of the head-to-tail junction of tropomyosin complexed with a fragment… · the same entry in another collection · chain F against F, TM-score 1.00
P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain B against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03069
Every structure of UniProt P58772
Every structure of UniProt P12620
Elsewhere: RCSB PDB 2Z5H · PDBe 2Z5H · UniProt P03069 · UniProt P58772 · UniProt P12620

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