Research workbench
Crystal structure of SPCIA1/ASF1 complexed with CAC2 peptide
Analyse Crystal structure of SPCIA1/ASF1 complexed with CAC2 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Z3F
- Type
- protein
- Length
- 1,370 residues
- Chains
- 19
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone chaperone CIA1; SPAC26H5.03 protein
- UniProt
- O74515, O13985
- Pockets
- 17 · best druggability 0.79
Structure
x-ray diffraction · 6 distinct chains · 12% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, G, H | Histone chaperone CIA1 | protein | 160 | 12% helix, 49% strand | O74515 |
| I, J, M, N, O, P | SPAC26H5.03 protein | protein | 10 | 0% helix, 60% strand | O13985 |
| K | SPAC26H5.03 protein | protein | 7 | 0% helix, 43% strand | O13985 |
| L | SPAC26H5.03 protein | protein | 9 | 0% helix, 33% strand | O13985 |
| F | Histone chaperone CIA1 | protein | 159 | 14% helix, 48% strand | O74515 |
| Q, R, T | SPAC26H5.03 protein | protein | 5 | 0% helix, 0% strand | O13985 |
Pockets
17 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 708 | 0.79 | 0.83 | 85 | empty |
| 2 | 496 | 0.71 | 0.80 | 49 | empty |
| 3 | 404 | 0.70 | 0.82 | 51 | empty |
| 4 | 609 | 0.66 | 0.76 | 63 | empty |
| 5 | 362 | 0.63 | 0.79 | 48 | empty |
Interfaces
39 interfaces between chains.
- E–G · 888 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 885 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 873 Ų buried · 6 hydrogen bonds · protein-protein
- F–H · 870 Ų buried · 7 hydrogen bonds · protein-protein
- D–H · 583 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2Z3F · Crystal structure of spCia1/Asf1 complexed with Cac2 peptide · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74515
- Every structure of UniProt O13985
- Elsewhere: RCSB PDB 2Z3F · PDBe 2Z3F · UniProt O74515 · UniProt O13985
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