Research workbench
Crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit from aquifex aeolicus
Analyse Crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Z04
- Type
- protein
- Length
- 634 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosylaminoimidazole carboxylase ATPase subunit
- EC
- 4.1.1.21
- UniProt
- O66608
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21) | protein | 309 | 32% helix, 31% strand | O66608 |
| B | Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21) | protein | 325 | 31% helix, 30% strand | O66608 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.80 | 0.98 | 20 | empty |
| 2 | 530 | 0.63 | 0.76 | 59 | SO4 |
| 3 | 491 | 0.61 | 0.75 | 61 | SO4 |
| 4 | 71 | 0.41 | 0.79 | 14 | empty |
| 5 | 65 | 0.37 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1551 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 2Z04 · Crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit from Aquifex… · the same entry in another collection · chain A against A, TM-score 1.00
- O66608 · AlphaFold monomer V2.0 prediction for N5-carboxyaminoimidazole ribonucleotide synthase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O66608
- Elsewhere: RCSB PDB 2Z04 · PDBe 2Z04 · UniProt O66608
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.