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Crystal structure of aspartate semialdehyde dehydrogenase from thermus thermophilus HB8

Analyse Crystal structure of aspartate semialdehyde dehydrogenase from thermus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2YV3
Type: protein
Length: 656 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aspartate-semialdehyde dehydrogenase
EC: 1.2.1.11
UniProt: Q5SKU8
Pockets: 8 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)	protein	328	34% helix, 24% strand	Q5SKU8

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	331	0.58	0.77	40	empty
2	50	0.56	0.90	17	empty
3	238	0.52	0.76	32	empty
4	57	0.42	0.82	15	empty
5	57	0.36	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 2580 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

2YV3 · Crystal Structure of Aspartate Semialdehyde Dehydrogenase from Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SKU8
Elsewhere: RCSB PDB 2YV3 · PDBe 2YV3 · UniProt Q5SKU8

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