Research workbench
Structure of the SCL:E47 complex bound to DNA
Analyse Structure of the SCL:E47 complex bound to DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YPB
- Type
- protein + DNA
- Length
- 163 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell acute lymphocytic leukemia protein 1; Transcription factor E2-alpha; Ebox forward…
- UniProt
- P17542, P15923
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 4 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-cell acute lymphocytic leukemia protein 1 | protein | 67 | 81% helix, 0% strand | P17542 |
| B | Transcription factor E2-alpha | protein | 74 | 78% helix, 0% strand | P15923 |
| E | Ebox forward | dna | 11 | — | — |
| F | Ebox reverse | dna | 11 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 173 | 0.81 | 0.97 | 25 | empty |
| 2 | 71 | 0.40 | 0.80 | 14 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1109 Ų buried · 2 hydrogen bonds · protein-protein
- E–F · 470 Ų buried · 45 hydrogen bonds · nucleic-nucleic
- B–F · 459 Ų buried · 8 hydrogen bonds · protein-nucleic
- A–E · 416 Ų buried · 10 hydrogen bonds · protein-nucleic
- A–F · 223 Ų buried · 2 hydrogen bonds · protein-nucleic
Compared structures
- 2YPB · Structure of the SCL:E47 complex bound to DNA · the same entry in another collection · chain A against A, TM-score 1.00
- P15923 · AlphaFold monomer V2.0 prediction for transcription factor E2-alpha (P15923) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P17542 · AlphaFold monomer V2.0 prediction for T-cell acute lymphocytic leukemia protein 1 (P17542) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17542
- Every structure of UniProt P15923
- Elsewhere: RCSB PDB 2YPB · PDBe 2YPB · UniProt P17542 · UniProt P15923
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