Research workbench
Crystal structure of the human spir-1 kind fsi domain in complex with the fsi peptide
Analyse Crystal structure of the human spir-1 kind fsi domain in complex with the fsi… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YLE
- Type
- protein
- Length
- 192 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein spire homolog 1; Formin-2
- UniProt
- Q08AE8, Q9NZ56
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein spire homolog 1 | protein | 171 | 53% helix, 8% strand | Q08AE8 |
| B | Formin-2 | protein | 21 | 29% helix, 14% strand | Q9NZ56 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.38 | 0.80 | 15 | empty |
| 2 | 71 | 0.32 | 0.74 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1044 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 2YLE · Crystal structure of the human Spir-1 KIND FSI domain in complex with the FSI peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q08AE8 · AlphaFold monomer V2.0 prediction for protein spire homolog 1 (Q08AE8) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q9NZ56 · AlphaFold monomer V2.0 prediction for formin-2 (Q9NZ56) · a predicted model of the same protein · chain B against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08AE8
- Every structure of UniProt Q9NZ56
- Elsewhere: RCSB PDB 2YLE · PDBe 2YLE · UniProt Q08AE8 · UniProt Q9NZ56
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