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Crystal structure of E. COLI regulator of ribonuclease activity a (rraa) bound to fragment of dead-box protein rhlb
Analyse Crystal structure of E. COLI regulator of ribonuclease activity a (rraa) bound… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YJV
- Type
- protein
- Length
- 1,905 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulator of ribonuclease activity a; ATP-dependent RNA helicase rhlb
- EC
- 3.6.4.12
- UniProt
- P0A8R0
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 5 distinct chains · 19% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, E, G, H, J, K | Regulator of ribonuclease activity a | protein | 158 | 20% helix, 35% strand | P0A8R0 |
| D, F, I | Regulator of ribonuclease activity a | protein | 157 | 19% helix, 38% strand | P0A8R0 |
| L | Regulator of ribonuclease activity a | protein | 155 | 21% helix, 39% strand | P0A8R0 |
| M | ATP-dependent RNA helicase rhlb (EC 3.6.4.12) | protein | 6 | 0% helix, 0% strand | — |
| N | ATP-dependent RNA helicase rhlb (EC 3.6.4.12) | protein | 9 | 0% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 658 | 0.76 | 0.82 | 74 | empty |
| 2 | 655 | 0.76 | 0.82 | 72 | empty |
| 3 | 729 | 0.75 | 0.81 | 84 | empty |
| 4 | 609 | 0.74 | 0.81 | 66 | empty |
| 5 | 319 | 0.68 | 0.83 | 34 | empty |
Interfaces
29 interfaces between chains.
- J–K · 498 Ų buried · 8 hydrogen bonds · protein-protein
- K–L · 486 Ų buried · 8 hydrogen bonds · protein-protein
- E–F · 484 Ų buried · 8 hydrogen bonds · protein-protein
- G–I · 482 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 480 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2YJV · Crystal structure of E. coli regulator of ribonuclease activity A (RraA) bound to… · the same entry in another collection · chain N against N, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A8R0
- Elsewhere: RCSB PDB 2YJV · PDBe 2YJV · UniProt P0A8R0
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