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Crystal structure of the N-terminal IG1-2 module of human receptor protein tyrosine phosphatase lar

Analyse Crystal structure of the N-terminal IG1-2 module of human receptor protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2YD5
Type: protein
Length: 199 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase F
EC: 3.1.3.48
UniProt: P10586
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48)	protein	199	8% helix, 54% strand	P10586

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	228	0.53	0.77	27	empty
2	111	0.38	0.74	18	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2YD5 · Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine… · the same entry in another collection · chain A against A, TM-score 1.00
P10586 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase F… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10586
Elsewhere: RCSB PDB 2YD5 · PDBe 2YD5 · UniProt P10586

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