Research workbench
Structure of the fusidic acid resistance protein fusc
Analyse Structure of the fusidic acid resistance protein fusc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YB5
- Type
- protein
- Length
- 419 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative fusidic acid resistance protein
- UniProt
- Q6GD50
- Ligands
- ZN
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative fusidic acid resistance protein | protein | 204 | 40% helix, 20% strand | Q6GD50 |
| F | Putative fusidic acid resistance protein | protein | 215 | 40% helix, 21% strand | Q6GD50 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, F
- EDO · 1,2-ethanediol · additive · 8 copies · chains F, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 730 | 0.77 | 0.82 | 54 | EDO |
| 2 | 183 | 0.64 | 0.85 | 25 | EDO |
| 3 | 141 | 0.57 | 0.82 | 19 | empty |
| 4 | 139 | 0.53 | 0.81 | 22 | empty |
| 5 | 138 | 0.50 | 0.79 | 19 | empty |
Interfaces
1 interface between chains.
- A–F · 1278 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2YB5 · Structure of the fusidic acid resistance protein FusC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GD50
- Elsewhere: RCSB PDB 2YB5 · PDBe 2YB5 · UniProt Q6GD50
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