Research workbench
Brichos domain of surfactant protein C precursor protein
Analyse Brichos domain of surfactant protein C precursor protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YAD
- Type
- protein
- Length
- 470 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Surfactant protein C brichos domain
- UniProt
- E5RI64
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 6 distinct chains · 22% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Surfactant protein C brichos domain | protein | 77 | 22% helix, 32% strand | E5RI64 |
| B | Surfactant protein C brichos domain | protein | 79 | 22% helix, 33% strand | E5RI64 |
| C | Surfactant protein C brichos domain | protein | 83 | 24% helix, 30% strand | E5RI64 |
| D | Surfactant protein C brichos domain | protein | 79 | 22% helix, 33% strand | E5RI64 |
| E | Surfactant protein C brichos domain | protein | 75 | 23% helix, 32% strand | E5RI64 |
| F | Surfactant protein C brichos domain | protein | 77 | 22% helix, 32% strand | E5RI64 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 432 | 0.73 | 0.83 | 52 | empty |
| 2 | 214 | 0.63 | 0.83 | 42 | empty |
| 3 | 203 | 0.61 | 0.82 | 43 | empty |
Interfaces
10 interfaces between chains.
- C–F · 752 Ų buried · 15 hydrogen bonds · protein-protein
- B–E · 643 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 636 Ų buried · 8 hydrogen bonds · protein-protein
- A–E · 629 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 582 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified, 12 disulfide (engineered, disulfide).
Compared structures
- 2YAD · BRICHOS domain of Surfactant protein C precursor protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E5RI64
- Elsewhere: RCSB PDB 2YAD · PDBe 2YAD · UniProt E5RI64
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