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Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase (variant D11N) with bound prfar

Analyse Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Y88
Type: protein
Length: 244 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoribosyl isomerase a
EC: 5.3.1.24, 5.3.1.16
UniProt: P60578
Ligands: 2ER
Pockets: 1 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoribosyl isomerase a (EC 5.3.1.24, 5.3.1.16)	protein	244	39% helix, 31% strand	P60578

Ligands and binding sites

2ER · [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[[(Z)-[(3R,4R)-3,4-dihydroxy-2-oxo-5-phosphonooxy-pentyl]iminomethyl]amino]imidazol-1-yl]-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	235	0.82	0.95	42	2ER

Compared structures

2Y88 · Crystal structure of mycobacterium tuberculosis phosphoribosyl isomerase (variant D11N)… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt P60578
Elsewhere: RCSB PDB 2Y88 · PDBe 2Y88 · UniProt P60578

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