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Structure of a designed meningococcal antigen (factor H binding protein, mutant G1) inducing broad protective immunity

Analyse Structure of a designed meningococcal antigen (factor H binding protein, mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Y7S
Type: protein
Length: 481 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Factor H binding protein
UniProt: Q9JXV4
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Factor H binding protein	protein	241	6% helix, 59% strand	Q9JXV4
B	Factor H binding protein	protein	240	6% helix, 62% strand	Q9JXV4

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	917	0.77	0.80	72	empty
2	109	0.40	0.76	31	empty
3	73	0.36	0.77	22	empty

Interfaces

1 interface between chains.

A–B · 1220 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

2Y7S · Structure of a designed meningococcal antigen (factor H binding protein, mutant G1)… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JXV4
Elsewhere: RCSB PDB 2Y7S · PDBe 2Y7S · UniProt Q9JXV4

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