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Crystal structure of the pH domain of human actin-binding protein anillin anln

Analyse Crystal structure of the pH domain of human actin-binding protein anillin anln in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Y7B
Type: protein
Length: 134 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin-binding protein anillin
UniProt: Q9NQW6
Pockets: 1 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin-binding protein anillin	protein	134	19% helix, 43% strand	Q9NQW6

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	193	0.51	0.77	25	empty

Compared structures

2Y7B · Crystal structure of the PH domain of human Actin-binding protein anillin ANLN · the same entry in another collection · chain A against A, TM-score 1.00
Q9NQW6 · AlphaFold monomer V2.0 prediction for anillin (Q9NQW6) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NQW6
Elsewhere: RCSB PDB 2Y7B · PDBe 2Y7B · UniProt Q9NQW6

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