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Laminin ALPHA5 chain N-terminal fragment

Analyse Laminin ALPHA5 chain N-terminal fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Y38
Type: protein
Length: 341 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Laminin subunit alpha-5
UniProt: Q61001
Ligands: NAG, PO4
Pockets: 4 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Laminin subunit alpha-5	protein	341	11% helix, 28% strand	Q61001

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
PO4 · Phosphate ion · ion · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.51	0.85	18	PO4
2	78	0.41	0.79	18	empty
3	68	0.39	0.79	20	empty
4	75	0.31	0.74	18	empty

Modifications

Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

2Y38 · Laminin ALPHA5 chain N-terminal fragment · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q61001
Elsewhere: RCSB PDB 2Y38 · PDBe 2Y38 · UniProt Q61001

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