Research workbench
The mechanisms of hamp-mediated signaling in transmembrane receptors - the A291V mutant
Analyse The mechanisms of hamp-mediated signaling in transmembrane receptors - the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Y21
- Type
- protein
- Length
- 631 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hamp
- UniProt
- O28769
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 9 distinct chains · 66% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, I | Hamp | protein | 52 | 67% helix, 0% strand | O28769 |
| B | Hamp | protein | 53 | 68% helix, 0% strand | O28769 |
| D, F | Hamp | protein | 55 | 69% helix, 0% strand | O28769 |
| E | Hamp | protein | 54 | 61% helix, 0% strand | O28769 |
| G | Hamp | protein | 52 | 63% helix, 0% strand | O28769 |
| H | Hamp | protein | 50 | 66% helix, 0% strand | O28769 |
| J | Hamp | protein | 54 | 69% helix, 0% strand | O28769 |
| K | Hamp | protein | 49 | 65% helix, 0% strand | O28769 |
| L | Hamp | protein | 53 | 62% helix, 0% strand | O28769 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 954 | 0.69 | 0.75 | 87 | empty |
| 2 | 296 | 0.53 | 0.75 | 34 | empty |
| 3 | 114 | 0.37 | 0.74 | 20 | empty |
| 4 | 103 | 0.35 | 0.74 | 17 | empty |
| 5 | 77 | 0.34 | 0.75 | 20 | empty |
Interfaces
22 interfaces between chains.
- A–B · 868 Ų buried · 13 hydrogen bonds · protein-protein
- I–J · 860 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 854 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 852 Ų buried · 12 hydrogen bonds · protein-protein
- K–L · 851 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 2Y21 · The mechanisms of HAMP-mediated signaling in transmembrane receptors - the A291V mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O28769
- Elsewhere: RCSB PDB 2Y21 · PDBe 2Y21 · UniProt O28769
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