Research workbench
Crystal structure of the complex between dosage compensation factors MSL1 and mof
Analyse Crystal structure of the complex between dosage compensation factors MSL1 and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Y0M
- Type
- protein
- Length
- 315 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable histone acetyltransferase MYST1; Male-specific lethal 1 homolog
- UniProt
- Q9H7Z6, Q6PDM1
- Ligands
- ACO, ZN
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable histone acetyltransferase MYST1 | protein | 273 | 34% helix, 23% strand | Q9H7Z6 |
| B | Male-specific lethal 1 homolog | protein | 42 | 79% helix, 0% strand | Q6PDM1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 484 | 0.71 | 0.81 | 59 | ACO |
| 2 | 109 | 0.42 | 0.77 | 23 | empty |
| 3 | 94 | 0.38 | 0.76 | 23 | empty |
| 4 | 81 | 0.35 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1056 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (oxidation, acetylation).
Compared structures
- 2Y0M · Crystal structure of the complex between dosage compensation factors MSL1 and mof · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H7Z6 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT8 (Q9H7Z6) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q6PDM1 · AlphaFold monomer V2.0 prediction for male-specific lethal 1 homolog (Q6PDM1) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H7Z6
- Every structure of UniProt Q6PDM1
- Elsewhere: RCSB PDB 2Y0M · PDBe 2Y0M · UniProt Q9H7Z6 · UniProt Q6PDM1
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