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A widespread family of bacterial cell wall assembly proteins

Analyse A widespread family of bacterial cell wall assembly proteins in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2XXQ
Type: protein
Length: 373 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CPS2A
UniProt: Q9ZII9
Ligands: ZTP
Pockets: 3 · best druggability 0.86

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CPS2A	protein	373	39% helix, 28% strand	Q9ZII9

Ligands and binding sites

ZTP · (2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl trihydrogen diphosphate · ligand · chains A
EDO · 1,2-ethanediol · additive · 5 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	821	0.86	0.88	68	EDO, ZTP
2	375	0.62	0.78	43	empty
3	75	0.52	0.85	26	empty

Compared structures

2XXQ · A widespread family of bacterial cell wall assembly proteins · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9ZII9
Elsewhere: RCSB PDB 2XXQ · PDBe 2XXQ · UniProt Q9ZII9

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