Research workbench
Dimeric archaeal cleavage and polyadenylation specificity factor with N-terminal kh domains (kh-cpsf) from methanosarcina mazei
Analyse Dimeric archaeal cleavage and polyadenylation specificity factor with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2XR1
- Type
- protein
- Length
- 1,216 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cleavage and polyadenylation specificity factor 100 kd subunit
- UniProt
- Q8PZ03
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cleavage and polyadenylation specificity factor 100 kd subunit | protein | 605 | 37% helix, 21% strand | Q8PZ03 |
| B | Cleavage and polyadenylation specificity factor 100 kd subunit | protein | 611 | 36% helix, 21% strand | Q8PZ03 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 358 | 0.81 | 0.91 | 50 | empty |
| 2 | 243 | 0.80 | 0.93 | 40 | empty |
| 3 | 829 | 0.74 | 0.78 | 71 | empty |
| 4 | 611 | 0.68 | 0.77 | 64 | empty |
| 5 | 77 | 0.54 | 0.86 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 830 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2XR1 · Dimeric archaeal cleavage and polyadenylation specificity factor with N-terminal kh… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8PZ03
- Elsewhere: RCSB PDB 2XR1 · PDBe 2XR1 · UniProt Q8PZ03
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.