Research workbench
Crystal structure of native chicken fibrinogen
Analyse Crystal structure of native chicken fibrinogen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EI3
- Type
- protein
- Length
- 1,896 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibrinogen
- UniProt
- P14448, Q02020, O93568
- Pockets
- 2 · best druggability 0.32
Structure
x-ray diffraction · 4 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibrinogen | protein | 159 | 0% helix, 0% strand | P14448 |
| B, E | Fibrinogen | protein | 395 | 0% helix, 0% strand | Q02020 |
| C, F | Fibrinogen | protein | 397 | 0% helix, 0% strand | O93568 |
| D | Fibrinogen | protein | 153 | 0% helix, 0% strand | P14448 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.32 | 0.73 | 28 | empty |
| 2 | 62 | 0.31 | 0.73 | 21 | empty |
Interfaces
10 interfaces between chains.
- B–C · 277 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 246 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 245 Ų buried · 0 hydrogen bonds · protein-protein
- D–E · 235 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 111 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1EI3 · Crystal structure of native chicken fibrinogen · the same entry in another collection · chain F against F, TM-score 1.00
- Q02020 · AlphaFold monomer V2.0 prediction for fibrinogen beta chain (Q02020) · a predicted model of the same protein · chain E against A, TM-score 0.83
- P14448 · AlphaFold monomer V2.0 prediction for fibrinogen alpha chain (P14448) · a predicted model of the same protein · chain D against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14448
- Every structure of UniProt Q02020
- Every structure of UniProt O93568
- Elsewhere: RCSB PDB 1EI3 · PDBe 1EI3 · UniProt P14448 · UniProt Q02020 · UniProt O93568
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