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NMR structure of the protein-unbound spliceosomal U4 snrna 5' stem loop

Analyse NMR structure of the protein-unbound spliceosomal U4 snrna 5' stem loop in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2XEB
Type
RNA
Length
33 nucleotides
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-R(P*GP*AP*UP*CP*GP*UP*AP*GP*CP*CP*AP*AP*UP*GP*AP* GP*GP*UP*U)-3'…
Pockets
1 · best druggability 0.39

Structure

solution nmr · 2 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A5'-R(P*GP*AP*UP*CP*GP*UP*AP*GP*CP*CP*AP*AP*UP*GP*AP* GP*GP*UP*U)-3'rna19——
B5'-R(P*GP*CP*CP*GP*AP*GP*GP*CP*GP*CP*GP*AP*UP*C)-3'rna14——

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11690.390.7317empty

Interfaces

1 interface between chains.

  • A–B · 853 Ų buried · 55 hydrogen bonds · nucleic-nucleic

Compared structures

  • 2XEB · NMR structure of the protein-unbound spliceosomal U4 snrna 5' stem loop · the same entry in another collection · chain A against A, TM-score 1.00

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