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Transcription factor ttgr H67A mutant

Analyse Transcription factor ttgr H67A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2XDN
Type: protein
Length: 822 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hth-type transcriptional regulator ttgr
UniProt: Q9AIU0
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Hth-type transcriptional regulator ttgr	protein	206	73% helix, 1% strand	Q9AIU0
B, D	Hth-type transcriptional regulator ttgr	protein	205	75% helix, 1% strand	Q9AIU0

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	545	0.82	0.88	43	empty
2	523	0.81	0.87	39	empty
3	559	0.80	0.86	47	empty
4	541	0.80	0.86	39	empty
5	179	0.45	0.75	34	empty

Interfaces

4 interfaces between chains.

C–D · 2273 Å² buried · 33 hydrogen bonds · protein-protein
A–B · 2234 Å² buried · 35 hydrogen bonds · protein-protein
B–D · 256 Å² buried · 3 hydrogen bonds · protein-protein
A–C · 218 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2XDN · Transcription factor TtgR H67A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q9AIU0 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator ttgr (Q9AIU0) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9AIU0
Elsewhere: RCSB PDB 2XDN · PDBe 2XDN · UniProt Q9AIU0

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