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Multiple oligomeric forms of the pseudomonas aeruginosa rets sensor domain modulate accessibility to the ligand- binding site

Analyse Multiple oligomeric forms of the pseudomonas aeruginosa rets sensor domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2XBZ
Type: protein
Length: 270 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rets-hybrid sensor kinase
EC: 2.7.13.3
UniProt: Q9HUV7
Pockets: 2 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rets-hybrid sensor kinase (EC 2.7.13.3)	protein	132	6% helix, 52% strand	Q9HUV7
B	Rets-hybrid sensor kinase (EC 2.7.13.3)	protein	138	9% helix, 21% strand	Q9HUV7

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1161	0.79	0.81	70	empty
2	84	0.31	0.72	17	empty

Interfaces

1 interface between chains.

A–B · 596 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

2XBZ · Multiple oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HUV7
Elsewhere: RCSB PDB 2XBZ · PDBe 2XBZ · UniProt Q9HUV7

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