Research workbench
H.SALINARUM alkaline phosphatase
Analyse H.SALINARUM alkaline phosphatase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2X98
- Type
- protein
- Length
- 858 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alkaline phosphatase
- EC
- 3.1.3.1
- UniProt
- B0R9W3
- Ligands
- MG, ZN, NA, CL, PO4
- Pockets
- 1 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alkaline phosphatase (EC 3.1.3.1) | protein | 430 | 42% helix, 18% strand | B0R9W3 |
| B | Alkaline phosphatase (EC 3.1.3.1) | protein | 428 | 43% helix, 18% strand | B0R9W3 |
Ligands and binding sites
- MG · Magnesium ion · metal · 11 copies · chains A, B
- ZN · Zinc ion · metal · 4 copies · chains A, B
- NA · Sodium ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · 13 copies · chains A, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1148 | 0.83 | 0.84 | 112 | MG, CL |
Interfaces
1 interface between chains.
- A–B · 492 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2X98 · H.SALINARUM alkaline phosphatase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B0R9W3
- Elsewhere: RCSB PDB 2X98 · PDBe 2X98 · UniProt B0R9W3
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