Research workbench
Fructose binding periplasmic domain of hybrid two component system BT1754
Analyse Fructose binding periplasmic domain of hybrid two component system BT1754 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2X7X
- Type
- protein
- Length
- 601 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor protein
- EC
- 2.7.13.3
- UniProt
- Q8A6X1
- Ligands
- FRU, K, PO4
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor protein (EC 2.7.13.3) | protein | 301 | 46% helix, 21% strand | Q8A6X1 |
| B | Sensor protein (EC 2.7.13.3) | protein | 300 | 46% helix, 21% strand | Q8A6X1 |
Ligands and binding sites
- FRU · beta-D-fructofuranose · sugar · 2 copies · chains A, B
- K · Potassium ion · metal · 3 copies · chains A, B
- PO4 · Phosphate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 293 | 0.66 | 0.82 | 36 | PO4 |
| 2 | 270 | 0.65 | 0.82 | 40 | PO4 |
Interfaces
1 interface between chains.
- A–B · 1368 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 2X7X · Fructose binding periplasmic domain of hybrid two component system BT1754 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8A6X1
- Elsewhere: RCSB PDB 2X7X · PDBe 2X7X · UniProt Q8A6X1
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