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Crystal structure of a widely conserved GTPase era

Analyse Crystal structure of a widely conserved GTPase era in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1EGA
Type: protein
Length: 585 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (GTP-binding protein era)
UniProt: P06616
Ligands: SO4
Pockets: 5 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (GTP-binding protein era)	protein	292	36% helix, 24% strand	P06616
B	Protein (GTP-binding protein era)	protein	293	36% helix, 24% strand	P06616

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	709	0.73	0.79	70	SO4
2	769	0.72	0.78	64	SO4
3	117	0.38	0.75	26	empty
4	82	0.32	0.73	17	empty
5	78	0.31	0.73	16	empty

Interfaces

1 interface between chains.

A–B · 771 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1EGA · Crystal structure of a widely conserved GTPase era · the same entry in another collection · chain A against A, TM-score 1.00
P06616 · AlphaFold monomer V2.0 prediction for GTPase era (P06616) · a predicted model of the same protein · chain A against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06616
Elsewhere: RCSB PDB 1EGA · PDBe 1EGA · UniProt P06616

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